The PD-1/PD-L1 axis is a key immune checkpoint pathway that regulates T cell responses. When PD-1 on T cells binds to its ligand, PD-L1, expressed on tumor cells or antigen-presenting cells, it inhibits T cell activation and proliferation. LAG-3, another immune checkpoint molecule, also suppresses T cell responses by interacting with its ligand, MHC class II. Both PD-1 and LAG-3 are often upregulated on exhausted T cells in the tumor microenvironment, contributing to immune evasion.
is an investigational drug candidate developed by Celltrion . Based on publicly available information: ct-p44
| Parameter | Specification | | :--- | :--- | | | CT-P44 | | Input Voltage | 100-240 VAC, 50/60 Hz | | Output Voltage | 48 VDC (Adjustable 42-58V) | | Max Current | 90A | | Efficiency | ≥ 94% | | Cooling Method | Forced Air (Smart Fan) | | Dimensions | 450mm x 220mm x 150mm | | Weight | 7.2 kg (15.8 lbs) | | Operating Temp | -20°C to +50°C | The PD-1/PD-L1 axis is a key immune checkpoint