: Study of mutations, Mendelian inheritance, and complex genetic disorders. Why Students Use It
Many non-HLA risk genes are shared with other autoimmune diseases (type 1 diabetes, rheumatoid arthritis), suggesting common pathways of immune dysregulation, with the unique trigger (gluten) and tissue specificity (intestine) shaped by HLA-DQ.
This piece explores Fasano’s core contributions: the discovery of , the genetic constraints of gluten sensitivity, and the “three-legged stool” model of autoimmunity.
: Reviewers frequently praise Silvia Fasano's sections on genetics for being exceptionally clear and engaging.
Fasano’s most influential conceptual contribution is the :





