Bme Pain -

| Challenge | Engineering Solution (Ongoing) | |-----------|---------------------------------| | | Soft, stretchable polymers (PDMS, parylene-C); anti-inflammatory coatings (dexamethasone) | | Battery life (IPG replacement surgery) | Inductive charging; energy-harvesting from body motion/heat | | Interpatient variability in response | Machine learning personalization of stimulation patterns (Reinforcement Learning) | | Central side effects (tolerance, addiction) | Optogenetics combined with micro-LED implants (preclinical only) | | MRI compatibility | Carbon-based leads; RF choke filters |