Ideally, your C: drive is a Solid State Drive (SSD)—blazing fast but limited in capacity. Your secondary drive is often a Hard Disk Drive (HDD)—capacious but mechanically slower. When you move applications to the HDD, you are trading storage space for load times.
Some of the biggest "space hogs" don't follow Windows' global rules. You’ll need to manage these individually: change default install location windows 10