The end of life for Visual Studio 2010 Tools for Office Runtime marks the end of an era for developers who have built custom solutions for Microsoft Office using this technology. While it presents challenges, it also offers opportunities for developers to modernize their solutions, adopt newer technologies, and benefit from improved security, scalability, and maintainability. By understanding the implications and exploring alternatives, developers and users can ensure the continued success and security of their Office solutions.
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Additionally, as Microsoft pushes Windows 11 and Microsoft 365 Apps (formerly Office 365) updates, legacy runtimes are increasingly likely to encounter compatibility issues or "deprecation warnings." visual studio 2010 tools for office runtime end of life
To be clear, the VSTO runtime follows the lifecycle of the Visual Studio tools it supports: The end of life for Visual Studio 2010